|
KMID : 0043320080310040429
|
|
Archives of Pharmacal Research
2008 Volume.31 No. 4 p.429 ~ p.437
|
|
|
In Vitro Antioxidant and Anti-inflammatory Activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal
|
|
Kim Min-Jung
Han Jong-Min
Jin Yue-Yan
Baek Nam-In
Bang Myun-Ho
Chung Hae-Gon
Choi Myung-Sook
Lee Kyung-Tae
Sok Dai-Eun
Jeong Tae-Sook
|
|
|
Abstract
|
|
|
|
Oxidized low-density lipoprotein (oxLDL) plays a key role in the inflammatory processes of atherosclerosis. Jaceosidin isolated from the methanolic extracts of the aerial parts of Artemisia princeps Pampanini cv. Sajabal was tested for antioxidant and anti-inflammatory activities. Jaceosidin inhibited the LDL oxidation with values of 10.2 in the thiobarbituric acid-reactive substances (TBARS) assay as well as the macrophage-mediated LDL oxidation. The antioxidant activities of jaceosidin were exhibited in the conjugated diene production, relative electrophoretic mobility, and apoB-100 fragmentation on copper-mediated LDL oxidation. Jaceosidin also inhibited the generation of reactive oxygen species (ROS) concerning in regulation of signaling. And jaceosidin inhibited nuclear factor-kappa B activity, nitric oxide (NO) production, and suppressed expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-induced RAW264.7 macrophages.
|
|
|
KEYWORD
|
|
|
Artemisia princeps Pampanini cv, Sajabal, Jaceosidin, Antioxidant, Anti-inflammation, Macrophages, Atherosclerosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|